University of Virginia Health System

Department of Molecular Physiology and Biological Physics

Robert M. Berne Cardiovascular Research Center
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Our mission is to understand the role of signaling microdomains in mediating heterocellular communication within the vasculature. Using novel cell biology and proteomic approaches, we study how heterocellular communication impacts such diverse vascular pathologies as hypertension, atherosclerosis, and angiogenesis.

Isakson Lab Update

Three Isakson Lab members each receive a first-author publication in two months!


From left to right, Dr. Scott Johnston (post-doc), Katie Heberlein (graduate student) and Dr. Adam Straub (post-doc).

The papers are:
  • Johnstone S. R., J. Ross, M. J. Rizzo, A. C. Straub, P. Lampe, N. Leitinger, and B. E. Isakson. Differential Cx43 phosphorylation and smooth muscle cell proliferation, in vivo. Am J Pathol, In Press.
  • Straub A. C., S. R. Johnstone, M. J. Rizzo, K. R. Heberlein, A. K. Best, S. Boitano and B. E. Isakson. Connexin phosphorylation can regulate heterocellular communication between smooth muscle and endothelium. J Vasc Res, In Press.
  • Heberlein K. R., A. C. Straub, and B. E. Isakson. The myoendothelial junction: Breaking through the matrix? Microcirculation, Mar 28: 1-16, 2009.
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